Job Description

Reports to : VP, Drug Discovery Candidate You are passionate about the company’s mission and a self-starter with an inextinguishable fire to compete and succeed. You thrive in an environment that requires crisp judgment, pragmatic decision-making, rapid course-corrections, and comfort with market ambiguity. You discharge your duties within a culture of mutual team respect, high performance, humility, and humor. Candidate Responsibilities : Perform molecular docking simulations for protein-ligand and protein-protein interactions to identify peptide-based drug candidates Design, oversee synthesize and characterize D-peptides to drive SAR in supporting of drug discovery pipeline Lead chemically modified analogs, linker chemistry, bioconjugation, purification, analytical and biophysical assessments. Serves as an in-house D-peptide chemistry expert from discovery to CMC activities Manage CRO operations to ensure D-peptide moieties meet project needs Present data at scientific conferences and publish data in scientific journals aligned to company objectives Serve as an example of teamwork and collaboration with adherence the company Team Operating Agreement Candidate Skills and Experience MS or PhD in Organic Chemistry, Biochemistry, Biophysics, Chemical Biology or related field with 6-15 years of experience in the biotech / biopharmaceutical industry Deep experience in peptide (linear, cyclic, bicyclic etc.) chemistry and understanding multi-step organic synthesis is required. Hands-on experience with manual and automated systems for solid-phase synthesis of peptides is desired Strong experience of peptide structure and associated biophysical techniques to assess peptide structure, stability, formulation and behavior in solution Expertise in bioconjugation, half-life extension (PK), labeling chemistry, metabolic stability for peptides, especially those containing non-canonical amino acid Good track record of leading the design & optimization of therapeutic peptides from hit validation to clinical candidate nomination is required Experience in the discovery & development of peptide drug conjugation (PDC) or / and peptide radioligands is highly desirable Experience and productivity in a multi-disciplinary team involving working with peptide CRO, external partners and collaborators Strong record of innovation and productivity as a researcher, as exemplified by publications, grants, and / or patents Proficiency with Python and shell scripting in developing protein design Knowledge of contemporary computational protein design methods (AlphaFold2, RoseTTAFold) Experience with molecular docking software (e.g. RosetttaDock, AutoDock, HADDOCK) to guide structure-based peptide drug discovery Excellent oral and written communication skills Entrepreneurial spirit, self-starter with proper balance of scientific creativity and disciplined execution Location : This position is based in San Diego Compensation : Competitive base salary, stock options, and a benefits package including flexible PTO and first-class medical coverage. #J-18808-Ljbffr Aizen Therapeutics

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